Lipid bilayer degradation induced by SARS-CoV-2 spike protein as revealed by neutron reflectometry

Scientists at the Institut Laue-Langevin (ILL), in collaboration with the Paul Scherrer Institut (PSI), the Institut de Biologie Structurale (IBS), using deuterated lipids from ANSTO, have published new data on how the SARS-CoV-2 spike protein interacts with mammalian lung cell membranes allowing the viral RNA to enter human cells. The purpose of the SARS-CoV-2 spike protein is relatively well understood. The glycoprotein is responsible for the fusion event that allows the virus to enter human cells and cause infection and, for this reason, it has been the focus for most COVID-19 vaccines.

Article: https://www.nature.com/articles/s41598-021-93996-x

Press release: https://www.ill.eu/news-press-events/press-corner/press-releases/neutron-reflectometry-reveals-sars-cov-2-spike-protein-induces-lipid-stripping-from-cell-membrane

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